This program determines the class of G-proteins that couple to the GPCR, i.e. Gi/o,Gs and Gq/11. No evaluation of this program on promiscuous receptors have yet been performed. The program only reports the class of G-proteins, not the individual patterns that contributed to the prediction. For such a verbose output please download the program and/or the patterns or write an email to the authors requesting this feature.
The program requires the following paramters:
|Name of protein:||name the sequence for later assignment of the prediction|
|Protein sequence:||enter the complete protein sequence|
|Specifiction of intracellular loops:||enter the position of the first and last residue of the found intracellular moietities of the 7TM receptor. These are referred to as intracellular loops 1 to 3 and the C-terminus.|
|MSR offset||Extend (+) or shrink (-) the intracellular loops with respect to the boundaries given by X residues.|
If errors are found in the data entered, then the form is shown again below the list of errors with previously entered values already filled in for correction.